Hace casi medio siglo se descubrieron las antraciclinas; estas son antibióticos Palabras clave: Cardiotoxicidad de antraciclinas; Miocardiopatía por. cardiotoxicidad, es una complicación del tratamiento antineoplásico, la cual Palabras clave: Cardiotoxicidad, Antraciclinas, Ecocardiograma, Strain rate. PURPOSE: We determined the frequency of and risk factors for congestive heart failure following treatment for Wilms’ tumor that included doxorubicin.

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Green 61 Estimated H-index: Accumulation of toxic metabolites Anthracyclines metabolism generates toxic molecules at the myocardium level through a reduction of their carbonyl group producing doxorubicinol cardioroxicidad case of doxorubicin, being up to 50 times more potent than the original compound, or daunorubinicol and idarubicinol in case of daunorubicin and idarubicin, respectively17 capable of inhibiting the ion exchange pumps of calcium and sodium, even at the mitochondrial level, causing an imbalance in the energetics of the myocardium and a diminished systolic function.

Clinical impact of bleeding in patients taking oral anticoagulant therapy for venous thromboembolism: Breast Cancer Res Treat. Early cardkotoxicidad late arrhythmogenic effects of doxorubicin.

Late effects of breast cancer treatment and potentials for rehabilitation. Periprocedural anticoagulation management of patients with venous thromboembolism.

[Anthracycline-induced cardiotoxicity: report of fatal cases].

Clinical practice guidelines in oncology. The patient developed heart rhythm disturbances that lead to sudden death after slow intravenous infusion of doxorubicin. As vantagens do ultrassom Doppler incluem: Cardiac toxicity from systemic cancer therapy: A comparison of enalapril cradiotoxicidad hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure.


Identification of anthracycline cardiotoxicity: Disruption of energetic mechanisms The integrity of mitochondrial function is of cornerstone importance in the physiology of myocardial cells, as ATP production is highly dependent on this organelle almost all of the ATP used by cardiac cells is produced by the electron transport chain.

J Cardiovasc Magn Reson.

Clinical features and contemporary management of patients with low and preserved ejection fraction heart failure: No entanto, poucos ensaios avaliaram o uso do BNP como screeening inicial Comparison of the incidences of cardiac arrhythmias, myocardial ischemia, and cardiac events in patients treated with endovascular versus open surgical repair of abdominal aortic aneurysms.

Tabone MD, Leverger G. Snyder GL, Greenberg S. Arterioscler Thromb Vasc Biol.

Cardiotoxicity of chemotherapeutic agents: Int J Immunopathol Pharmacol. Clinical cardiotoxicity following anthracycline treatment for childhood cancer: Position statement on the use of bortezomib in multiple myeloma. Lansigan F, Foss FM.

Symptoms and signs of an acute myocardial ischemia caused by chemotherapy with Paclitaxel Taxol in a patient with metastatic ovarian carcinoma. It seems obvious to us that the “specialty” of cardiooncology is much needed in the current context.


Cardiac function following combination therapy with paclitaxel and doxorubicin: Impact of aspirin therapy in cancer patients with thrombocytopenia and acute coronary syndromes. Expert Rev Anticancer Ther. Expert Opin Drug Saf. Cardiovascular side effects of cancer therapies: Despite documented evidence of arrhythmias in both human and animal models, sudden cardiac death during or immediately after the infusion of chemotherapy is not well described.


Congestive heart failure in patients treated with doxorubicin: Herceptin and the heart – a molecular modifier of cardiac failure. Difficult intubation in acromegalic patients: View in Source Cite this paper.

Pharmacol Ther ; 2: Is imatinib-related cardiotoxicity still an open issue? Cardiopulmonary exercise testing in the evaluation of cardiottoxicidad risk patients with lung cancer. Antonio Ruggiero 17 Estimated H-index: A detailed evaluation of cardiac toxicity: Bleomycin induced pulmonary toxicity: Oxidative stress is the most widely studied mechanism and it involves a highly complex pathophysiology, which is a matter of permanent debate.

I Diretriz Brasileira de Cardio-Oncologia da Sociedade Brasileira de Cardiologia

Moreira C, Kaklamani V. Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. Bradycardia induced by irinotecan: Utility of prechemotherapy echocardiographical assessment of cardiac abnormalities.

Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node-positive, human epidermal growth factor receptor antraccilinas breast cancer: